The “Fight Club” star was seen giving his friend a pat on the back and playfully pointing at fans.
Clooney looked sharp in a sleek black suit layered over a black button-down shirt with no tie.
Pitt coordinated with the “ER” alum by ditching his tie and opting for a dapper tan suit over a white shirt. He accessorized with black sunglasses.
The “Ocean’s Eleven” co-stars were seen walking energetically together as they entered the theater.
Earlier in the evening, Pitt arrived at the premiere with his girlfriend, Ines de Ramon, on his arm.
The couple looked smitten as the Oscar winner cozied up to the jewelry designer, 31, for all to see — though she did not join him on the step-and-repeat with Clooney.
However, the “Descendants” star has clearly given their love his stamp of approval, as he and wife, Amal Clooney, were seen on a double date with Pitt and de Ramon in Venice last month.
Their lavish Italian night out came after the pals promoted their forthcoming Apple TV+ film at the Venice Film Festival, marking Pitt’s red carpet debut with his girlfriend after dating for nearly two years.
The Jon Watts-directed movie follows a fixer hired to cover up a high-profile crime, only for his night to spiral out of control when he is forced to work with an unexpected counterpart.
The project marks the first time Pitt and Clooney have reunited on screen since starring in their 2008 movie, “Burn After Reading.” Before that, they formed a close bond while co-starring in the “Ocean’s” franchise in the early 2000s.
The BFFs opened up about their friendship during a joint interview with GQ in August, with Clooney noting they have been pals “for a long time.”
“And it’s fun because we also check in on each other every once in a while, which is an important part of this. Things get complicated in life, and you always have to make sure everybody’s OK,” he said.